Impact of two annual single-dose mass drug administrations with diethylcarbamazine alone or in combination with albendazole on Wuchereria bancrofti microfilaraemia and antigenaemia in south India.
Identifieur interne : 008788 ( Main/Exploration ); précédent : 008787; suivant : 008789Impact of two annual single-dose mass drug administrations with diethylcarbamazine alone or in combination with albendazole on Wuchereria bancrofti microfilaraemia and antigenaemia in south India.
Auteurs : R. Rajendran [Inde] ; I P Sunish ; T R Mani ; A. Munirathinam ; S Md Abdullah ; N. Arunachalam ; K. SatyanarayanaSource :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 2004.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Albendazole (administration et posologie), Animaux, Antigènes d'helminthe (sang), Antihelminthiques (administration et posologie), Association de médicaments, Calendrier d'administration des médicaments, Diéthylcarbamazine (administration et posologie), Enfant, Enfant d'âge préscolaire, Filariose lymphatique (), Humains, Observance thérapeutique, Résultat thérapeutique, Wuchereria bancrofti, Études transversales.
- MESH :
- administration et posologie : Albendazole, Antihelminthiques, Diéthylcarbamazine.
- sang : Antigènes d'helminthe.
- Adolescent, Adulte, Animaux, Association de médicaments, Calendrier d'administration des médicaments, Enfant, Enfant d'âge préscolaire, Filariose lymphatique, Humains, Observance thérapeutique, Résultat thérapeutique, Wuchereria bancrofti, Études transversales.
English descriptors
- KwdEn :
- Adolescent, Adult, Albendazole (administration & dosage), Animals, Anthelmintics (administration & dosage), Antigens, Helminth (blood), Child, Child, Preschool, Cross-Sectional Studies, Diethylcarbamazine (administration & dosage), Drug Administration Schedule, Drug Therapy, Combination, Elephantiasis, Filarial (prevention & control), Humans, Patient Compliance, Treatment Outcome, Wuchereria bancrofti.
- MESH :
- chemical , administration & dosage : Albendazole, Anthelmintics, Diethylcarbamazine.
- chemical , blood : Antigens, Helminth.
- prevention & control : Elephantiasis, Filarial.
- Adolescent, Adult, Animals, Child, Child, Preschool, Cross-Sectional Studies, Drug Administration Schedule, Drug Therapy, Combination, Humans, Patient Compliance, Treatment Outcome, Wuchereria bancrofti.
Abstract
A two-arm community-based lymphatic filariasis elimination trial is being carried out in Tamil Nadu state, India to assess the effect of 2 annual single-dose mass drug administrations of diethylcarbamazine + albendazole (DEC + ALB) on microfilaraemia and antigenaemia in one arm, and diethylcarbamazine(DEC) alone in the other arm. In a cross-sectional survey at each time-point, 450-650 subjects in childhood (2-9 years old) and young adulthood (10-25 years old) were screened from each treatment arm. After 2 annual mass drug administrations, microfilaraemia prevalence in the 2-drug arm was reduced by 54% and 62% in the 2-9 year old and 10-25 year old groups respectively; and corresponding figures for the single-drug arm were 26% and 37%. Though higher reductions were recorded for geometric mean intensity of microfilaraemia in the 2-9 year old groups for both treatment arms, reduction was more pronounced in the 2-drug arm than the single drug arm (74% vs. 24%) in the 10-25 year old group. The reduction in the antigenaemia prevalence in the 2-9 year old group was evident in both treatment arms, but in the 10-25 year old group the reduction was only 16.8% in the 2-drug arm. Our results suggest that the annual, single-dose combination (DEC + ALB) mass treatment regimen has an enhanced effect against bancroftian filariasis compared to single-drug therapy.
PubMed: 15024928
Affiliations:
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Le document en format XML
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Rajendran</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Research in Medical Entomology (Indian Council of Medical Research), 9/4, Sarojini Street, Chinna Chokkikulam, Madurai, Tamil Nadu-625 002, India. crmeicmr@satyam.net.in</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Centre for Research in Medical Entomology (Indian Council of Medical Research), 9/4, Sarojini Street, Chinna Chokkikulam, Madurai, Tamil Nadu-625 002</wicri:regionArea><wicri:noRegion>Tamil Nadu-625 002</wicri:noRegion></affiliation></author><author><name sortKey="Sunish, I P" sort="Sunish, I P" uniqKey="Sunish I" first="I P" last="Sunish">I P Sunish</name></author><author><name sortKey="Mani, T R" sort="Mani, T R" uniqKey="Mani T" first="T R" last="Mani">T R Mani</name></author><author><name sortKey="Munirathinam, A" sort="Munirathinam, A" uniqKey="Munirathinam A" first="A" last="Munirathinam">A. Munirathinam</name></author><author><name sortKey="Abdullah, S Md" sort="Abdullah, S Md" uniqKey="Abdullah S" first="S Md" last="Abdullah">S Md Abdullah</name></author><author><name sortKey="Arunachalam, N" sort="Arunachalam, N" uniqKey="Arunachalam N" first="N" last="Arunachalam">N. Arunachalam</name></author><author><name sortKey="Satyanarayana, K" sort="Satyanarayana, K" uniqKey="Satyanarayana K" first="K" last="Satyanarayana">K. Satyanarayana</name></author></analytic><series><title level="j">Transactions of the Royal Society of Tropical Medicine and Hygiene</title><idno type="ISSN">0035-9203</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Albendazole (administration & dosage)</term><term>Animals</term><term>Anthelmintics (administration & dosage)</term><term>Antigens, Helminth (blood)</term><term>Child</term><term>Child, Preschool</term><term>Cross-Sectional Studies</term><term>Diethylcarbamazine (administration & dosage)</term><term>Drug Administration Schedule</term><term>Drug Therapy, Combination</term><term>Elephantiasis, Filarial (prevention & control)</term><term>Humans</term><term>Patient Compliance</term><term>Treatment Outcome</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Albendazole (administration et posologie)</term><term>Animaux</term><term>Antigènes d'helminthe (sang)</term><term>Antihelminthiques (administration et posologie)</term><term>Association de médicaments</term><term>Calendrier d'administration des médicaments</term><term>Diéthylcarbamazine (administration et posologie)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Filariose lymphatique ()</term><term>Humains</term><term>Observance thérapeutique</term><term>Résultat thérapeutique</term><term>Wuchereria bancrofti</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Albendazole</term><term>Anthelmintics</term><term>Diethylcarbamazine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Albendazole</term><term>Antihelminthiques</term><term>Diéthylcarbamazine</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Antigènes d'helminthe</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Cross-Sectional Studies</term><term>Drug Administration Schedule</term><term>Drug Therapy, Combination</term><term>Humans</term><term>Patient Compliance</term><term>Treatment Outcome</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Animaux</term><term>Association de médicaments</term><term>Calendrier d'administration des médicaments</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Filariose lymphatique</term><term>Humains</term><term>Observance thérapeutique</term><term>Résultat thérapeutique</term><term>Wuchereria bancrofti</term><term>Études transversales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A two-arm community-based lymphatic filariasis elimination trial is being carried out in Tamil Nadu state, India to assess the effect of 2 annual single-dose mass drug administrations of diethylcarbamazine + albendazole (DEC + ALB) on microfilaraemia and antigenaemia in one arm, and diethylcarbamazine(DEC) alone in the other arm. In a cross-sectional survey at each time-point, 450-650 subjects in childhood (2-9 years old) and young adulthood (10-25 years old) were screened from each treatment arm. After 2 annual mass drug administrations, microfilaraemia prevalence in the 2-drug arm was reduced by 54% and 62% in the 2-9 year old and 10-25 year old groups respectively; and corresponding figures for the single-drug arm were 26% and 37%. Though higher reductions were recorded for geometric mean intensity of microfilaraemia in the 2-9 year old groups for both treatment arms, reduction was more pronounced in the 2-drug arm than the single drug arm (74% vs. 24%) in the 10-25 year old group. The reduction in the antigenaemia prevalence in the 2-9 year old group was evident in both treatment arms, but in the 10-25 year old group the reduction was only 16.8% in the 2-drug arm. Our results suggest that the annual, single-dose combination (DEC + ALB) mass treatment regimen has an enhanced effect against bancroftian filariasis compared to single-drug therapy.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Abdullah, S Md" sort="Abdullah, S Md" uniqKey="Abdullah S" first="S Md" last="Abdullah">S Md Abdullah</name><name sortKey="Arunachalam, N" sort="Arunachalam, N" uniqKey="Arunachalam N" first="N" last="Arunachalam">N. Arunachalam</name><name sortKey="Mani, T R" sort="Mani, T R" uniqKey="Mani T" first="T R" last="Mani">T R Mani</name><name sortKey="Munirathinam, A" sort="Munirathinam, A" uniqKey="Munirathinam A" first="A" last="Munirathinam">A. Munirathinam</name><name sortKey="Satyanarayana, K" sort="Satyanarayana, K" uniqKey="Satyanarayana K" first="K" last="Satyanarayana">K. Satyanarayana</name><name sortKey="Sunish, I P" sort="Sunish, I P" uniqKey="Sunish I" first="I P" last="Sunish">I P Sunish</name></noCountry><country name="Inde"><noRegion><name sortKey="Rajendran, R" sort="Rajendran, R" uniqKey="Rajendran R" first="R" last="Rajendran">R. Rajendran</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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